πŸ€– Into AI too? Top papers, code & models, every morning β˜•Distill AI β†’
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heart failure biomarkers|
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✨ heart failure biomarkers Γ—βœ¨ Protein structure prediction Γ—
πŸ‘€ Follow researchers
Eric Topol|
Eric Topol
Scripps Research Β· 600+ papers
πŸ‘€ Eric Topol Γ—

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πŸ‘€ From researchers you follow
πŸ‘€ ELENA REYESmedRxiv Β· 3d
High-Sensitivity Troponin for Early Myocardial Infarction Diagnosis
E. Topol
πŸ‘€ ELENA REYESmedRxiv Β· 12d
Beta-Blocker Therapy After Acute Myocardial Infarction: A Randomized Trial
S. Khera, R. Krittanawong, M. Cobb … E. Topol
✨ Your custom topics
✨ HEART FAILURE BIOMARKERSIEEE TMI · 5h
Coronary CT Angiography versus Functional Testing in Stable Chest Pain
S. Nakamura, R. Patel, et al.
Neurology4h agoThe Lancet 2026CODEπŸ”₯ HOT
Tirzepatide Once-Weekly for the Treatment of Obesity in Adults Without Diabetes β†—
Jastreboff, Aronne, Ahmad et al.
SUMMARY In adults with obesity but without diabetes, tirzepatide once weekly produced a mean weight reduction of about 21% at 72 weeks, with substantial and sustained reductions across all doses compared with placebo.
The 21% mean weight reduction at 72 weeks is striking β€” curious whether the benefit holds in our older patients with HFpEF.
Chat with paper β†’Read β†’Save to Zotero+ List
Endocrinology6h agoNEJM 2025CODETRIALπŸ”₯ HOT
Lecanemab in Early Alzheimer's Disease: 18-Month Cognitive Outcomes β†—
van Dyck, Swanson, Aisen, et al.
SUMMARY In participants with early Alzheimer's disease, lecanemab reduced brain amyloid burden and resulted in moderately less decline on measures of cognition and function than placebo at 18 months.
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Neurology8h agoThe Lancet 2026CODE
Pembrolizumab Plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer β†—
Gandhi, Rodriguez-Abreu, Gadgeel et al.
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Trending in Medicine
TRENDING5h agoCODETRIAL
Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes β†—
Lincoff, Brown-Frandsen, Colhoun et al. Β· Cleveland Clinic
SUMMARY Fully open VLM family trained with single-stage RL on a 600K-sample dataset spanning 59 datasets and six visual reasoning categories. In adults with cardiovascular disease and obesity but without diabetes, weekly semaglutide reduced major adverse cardiovascular events by 20% versus placebo.
Chat with paper β†’Read β†’Save to Zotero+ List
Recent Clinical Trials
TRIALPython2d ago⭐ 8.2K
Semaglutide in Heart Failure With Preserved Ejection Fraction
Phase 3 trial now recruiting β€” heart failure (HFpEF)
Now Recruiting πŸ€—
πŸ€— MODELPhase 31d ago❀ 4.8K
CAR-T Therapy in Relapsed or Refractory Large B-Cell Lymphoma
Phase 2 trial now recruiting β€” diffuse large B-cell lymphoma
πŸ“° Your Daily Medical News
FDA approves first once-daily oral GLP-1 for type 2 diabetes
TechCrunch Β· 2h agoTrials
Large trial finds intensive blood-pressure control cuts stroke risk
The Verge Β· 5h agoCardiology
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Search by meaning, not keywords πŸ”

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biomarkers for early sepsis detection
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96% matchmedRxiv Β· 2021
Procalcitonin-Guided Antibiotic Therapy in Sepsis: A Randomized Trial
M. Singer, C. Deutschman, J. Cohen et al.
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91% matchmedRxiv Β· 2023
Early Goal-Directed Therapy for Septic Shock: A Multicenter Trial
E. Rivers, B. Nguyen, S. Havstad et al.
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Balanced Crystalloids versus Saline in Critically Ill Adults
2/50 questions
What is the key contribution?
Key Contribution
The study reports a large multicenter trial comparing balanced crystalloids with saline for fluid resuscitation in critically ill adults.
Two main findings:
  • State-of-the-art models drop 30–50% on novel combinations.
  • A contrastive training objective closes ~60% of that gap.
Ask another question...
Balanced Crystalloids versus Saline in Critically Ill Adults
A. AuthorsΒΉ, B. AuthorsΒ², C. AuthorsΒΉ Β· ΒΉUniversity Lab Β· Β²Research Org
Abstract
1. Introduction
2. Methodology
Page 1 of 14

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3/15 questions this month
What do the papers I saved this month agree on about GLP-1 therapies in heart failure?
Across your 6 saved papers
Three converge on a clear point:
  • SGLT2 inhibitors reduce heart-failure hospitalization regardless of ejection fraction β€” in EMPEROR-Preserved and (2021).
  • GLP-1 agonists also cut cardiovascular events ~10Γ— in non-diabetic obesity (SELECT).
Where they differ: EMPEROR-Preserved enrolled a broad EF range, while DELIVER focused on EF above 40%.
Ask about your bookmarks...

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Online now (8)
MOLS
M
Maya ChenPRO2m
New trial: tirzepatide in HFpEF β€” 38% fewer heart-failure events. Curious what @Omar Farouk thinks for video.
πŸ”₯ 4πŸš€ 2πŸ‘ 6
O
Omar Farouk
Online
Saw your post β€” did they see benefit in the elderly subgroup?
Yes! Sending the preprint now.
πŸ“„ tirzepatide-hfpef.pdf

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